ABSTRACT
We aimed to detect the drug resistant and molecular characteristic of Klebsiella Pneumoniae (KP) isolated from different hosts origin,and to investigate the infection possibility between animals and humans.A total of 98 KP strains were collected in Henan Province from March 2013 to December 2014.Drug-resistance to 15 antibiotics was detected by K-B diffu sion methods.The phenotype of produce mucus was determined by stringing test.Seven drug-resistant gene and 2 virulence gene were amplified by PCR technique.Molecular types were analysis by MLST.The resistant rate of KP isolated from noso comial was higher than those isolated from animals.Among animal strains,the resistant rate of KP isolated from chickens and pigs were higher than that from rabbits and dogs.The multidrug resistant (MDR) of nosocomial isolates were the highest (74.19％).There were 18 STs among 98 KP strains.The main prevalent types were ST37 in chicken,ST258 in pigs,ST60 in rabbits,ST11 in dogs and nosocomial respectively.ST11 was common epidemic types among nosocomial,dogs and pigs.ST235 was common molecular types among chicken and human.ST258 existed in both nosocomial and pigs.The rmpA gene and magA gene were detected in ST11,ST235 and ST 258,producing higher mucus.The blaKPC gene was 54.84％ in nosocomial strains,but not been detected in dog and rabbit strains.The distribution of ESBLs gene in nosocomial was higher than those in animals,but qnrA gene and qnrB gene were higher in chicken than in human.The multidrug resistant gene was the highest distribution in ST11,ST258 and ST235.There were some differences in phenotype of drug-resistance,producing mucus and molecular characteristics,but ST11,ST258 and ST235 were common types of KP isolates from different host origins.
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the therapeutic efficacy of Yinxing Damo (YXDM) combined with Betahistine Hydrochloride Injection (BHI) on vertebra basilar artery ischemic vertigo (VBIV).</p><p><b>METHODS</b>Ninety patients with VBIV were randomly divided into two groups; 45 patients (the treated group) were treated with YXDM and BHI intravenous dripping, once a day for 14 days. Another 45 patients (control group) were treated with Xueshuantong and BHI intravenous dripping, once daily for 14 days. The clinical syndromes and the index of the transcranial Doppler (TCD) and hemorheology were observed.</p><p><b>RESULTS</b>The total effective rate was 100% in the treated group, which was better than that in the control group 90.5%, (P < 0.05). The indexes of TCD and hemorheology in the treated group were obviously improved after treatment, (P < 0.01).</p><p><b>CONCLUSION</b>YXDM combined with BHT injection had better effect in treating patients with VBIV is an ideal drug for VBIV.</p>